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Using a neuronal specic Cre recombinaseunder the control of a Nestin enhancer the Lozano group explored how the loss ofMdm2 impacted neuronal cell development. (2007) PET amyloid ligand[11C]PiB uptake is increased in mild cognitive impairment (2007) PET amyloid ligand[11C]PiB uptake is increased in mild cognitive impairment. On one hand Pin1 enhances complex formationbetween p63 and mutant p53 [ 11], blocking transcriptional activation of the anti-metastatic p63 targets CCNG2 and SHARP1 [ 22] On one hand Pin1 enhances complex formationbetween p63 and mutant p53 [ 11], blocking transcriptional activation of the anti-metastatic p63 targets CCNG2 and SHARP1 [ 22].
Quantitativeand qualitative components are mixed to maximize on their “complementary strengthsand nonoverlapping weaknesses” to address a given research problem, in context, asthoroughly and completely as possible (Creswell & Plano Clark, 2011).